[Geuvadis_rna_analysis] analysis updates

Hello, First a question: Who would like to present on Thursday's analysis group call? Next week we should discuss splicing QTLs (with results from Jean and myself), but this week's slot is free. Then a couple of analysis updates: - I've done some analysis on miRNA-mRNA interactions; namely on whether miRNA-cis-eQTLs show increased trans-signal to the targets of these miRNAs. The answer is maybe yes - the signal is small but significant. See http://sanabre.net/geuvadis/index.php/MiRNA-mRNA_interaction . - I've updated some normalizations of quantifications - I let some of you know about these already during the weekend, but for FYI for eneryone. Details in http://sanabre.net/geuvadis/index.php/Basic_methodology#Normalization_of_th… . These are quantifications done jointly on the 462 samples by PEER, and then transforming the residuals to standard normal (*norm* in the filename). There are files for miRNAs (full and seed-pooled), exons, splice junctions, introns, and transcripts in the directories below: /upload/geuvadis/wp4_rnaseq/main_project/analysis_data/mirna/quantification_tables /upload/geuvadis/wp4_rnaseq/main_project/analysis_data/quantification/exon/ /upload/geuvadis/wp4_rnaseq/main_project/analysis_data/quantification/splice_junction-intron /upload/geuvadis/wp4_rnaseq/main_project/analysis_data/quantification/splice_junction-intron /upload/geuvadis/wp4_rnaseq/main_project/analysis_data/quantification/transcript cheers, Tuuli -- Tuuli Lappalainen, PhD Department of Genetic Medicine and Development University of Geneva Medical School CMU / Rue Michel-Servet 1 1211 Geneva 4 Switzerland Tel. +41-(0)22-3795550 tuuli.lappalainen(a)unige.ch