Hi all - especially Thasso and Micha, In order to correct/filter for allelic mapping bias in Geuvadis analysis as we've discussed before, I've simulated reads over 1000g variants. The fastq files are available for mapping in /upload/geuvadis/wp4_rnaseq/main_project/external_data/genetic_variation/allelic_mapping_simulation/fastq . These should be mapped with GEM and converted to bam similarly to our real data, except that these are single-end reads. It actually became a lot less reads than I anticipated because I ended up taking only sites that are polymorphic in our populations: it's about 300M reads in total, so I hope that this could be done pretty soon :-) At least, could you please check already this week that the files are OK so that I can modify them if needed without further delay. Further details in the wiki: http://www.geuvadis.org/group/geuvadis/wikis/-/wiki/Main%20Geuvadis%20Wiki/… cheers, Tuuli -- Tuuli Lappalainen, PhD Department of Genetic Medicine and Development University of Geneva Medical School CMU / Rue Michel-Servet 1 1211 Geneva 4 Switzerland Tel. +41-(0)22-3795550 tuuli.lappalainen(a)unige.ch