Hello all, I'd like to update to Gencode v12 gene annotation (Ensembl 67) in the Geuvadis RNAseq project after all. After a lot of discussions, I'm now taking back my last week's decision to stick to v7. That would have made some things easier but others more difficult, and I wouldn't want us to lose any power because of an outdated annotation that might make a bit of a difference especially in the LoF variant annotations. It's not too late to switch yet - we'll need to rerun the transcript quantifications though. We'll let you know when it's done. No one expressed a strong opinion about this before, but if you disagree, please say it now. best regards, Tuuli -- Tuuli Lappalainen, PhD Department of Genetic Medicine and Development University of Geneva Medical School CMU / Rue Michel-Servet 1 1211 Geneva 4 Switzerland Tel. +41-(0)22-3795550 tuuli.lappalainen(a)unige.ch