Re: [Geuvadis_rna_analysis] analysis group TC October 18

Hello, Here are the minutes of the call. The next call will be in one week, October 25th at 2pm CET. - We discussed some analysis updates - analysis seems to be progressing quite fast now and many things are finished or close to finished, as they should by now. - Thomas presented RNA editing analyses. We have 113 cases where known RNA editing sites show editing in our data using very stringent criteria. 11 of these show significant population differences. Tuuli has the data and will do QTL analysis on the proportion of editing. - Tuuli presented allele-specific splicing analyses. ASAS appears to be as common as ASE and we can assess that for thousands of sites per individual. ASE and ASAS signals are commonly shared, suggesting that transcript structure variation is major contributor to ASE signal. - We continued with a QC subgroup call and went through Peter's outline of figures for the QC companion. Most of the analysis is done, and Peter will put together a todo list of the remaining action items. best, Tuuli Tuuli Lappalainen, PhD Department of Genetic Medicine and Development University of Geneva Medical School CMU / Rue Michel-Servet 1 1211 Geneva 4 Switzerland Tel. +41-(0)22-3795550 tuuli.lappalainen(a)unige.ch On /17/1012 19:41 PM, Tuuli Lappalainen wrote: